Tuesday, January 27, 2015
FAIRFIELD-SUISUN, CALIFORNIA
99 CENTS

Trial results promising for curing puppies’ parvo

Parvo Puppies

This May 30, 2014, photo provided by KC Pet Project, shows two puppies that were treated for canine parvovirus at the Kansas City Pet Project, one of the largest shelters in the country. A Grand Forks, N.D., company is testing a cure for the disease that would make it cheaper and easier to treat the dogs. (AP Photo/KC Pet Project)

By
From page A5 | June 02, 2014 |

GRAND FORKS, N.D. — A North Dakota company that discovered an antibody technology while trying to cure flocks of dying geese is using its research for a more warm and fuzzy purpose: saving puppies.

Early tests performed on about 50 puppies in seven states for Grand Forks-based Avianax have resulted in a 90 percent cure rate for canine parvovirus, which spreads through animal waste and direct contact between dogs, usually at kennels, shelters and shows. Some puppies die from the virus and others are euthanized because the antibiotics and other medicine needed to treat it can be too expensive – sometimes up to $2,000 – and take too long.

It isn’t clear how many dogs contract parvo annually, since the disease isn’t required to be reported. At the Kansas City Pet Project, one of eight test sites and among the largest shelters in the United States, about five cases a month wind up on the “parvo ward.” Officials with the Missouri shelter believe the treatment will lead to a dramatic increase in their “parvo graduates.”

“When the box arrived we were yelling, ‘Woo, the geese antibodies are here!'” shelter spokeswoman Tori Fugate said. “Just the fact that someone is caring out there is pretty remarkable. A lot of open admission shelters choose to not treat parvo because it’s considered too much of a resource.”

Avianax chief operating officer Richard Glynn hopes to start selling the parvoONE antibody-based treatment – that is, harvested from the yokes of goose eggs – for $75 a dose by next spring.

“I think there will be a lot of puppy owners who will be very happy,” Glynn said.

The U.S. Department of Agriculture issued a conditional permit for the field trials that are taking place in sites in Missouri, North Dakota, Minnesota, Iowa, Texas, North Carolina and Arizona. Such permits are normally reserved for outbreaks or other dire situations, but this one passed muster because there’s no product specifically targeted for parvovirus, said Jeremy Vrchota, Avianax’s sales director and regulatory liaison.

Officials with the USDA’s Animal and Plant Inspection Service did not respond to phone messages left by The Associated Press.

The company’s path to puppy love began a decade ago after a mysterious disease – later found to be West Nile virus – spread among flocks at the South Dakota-based Schiltz Goose Farm, the largest goose producer in North America. Farm owners James and Richard Schiltz and Glynn, who was working for them, found researchers at the University of North Dakota who were interested in the project.

The group, led by Dr. David Bradley, the UND medical school’s chair of microbiology and immunization, discovered antibodies in the geese that they could purify and put back into other birds. The treatment worked.

“We went to the Mayo Clinic and they looked at all our work,” Glynn said. “They called it a game-changing technology.”

Avianax quickly found promising links between goose antibodies and treatments for other diseases, including rabies, dengue fever, avian flu and some cancers. Because they didn’t have the money or time to explore testing for human diseases, the group set their sights on the veterinary market and eventually settled on saving puppies.

Treating parvovirus currently can cost, at a minimum, $500 for antibiotics, intravenous fluids, painkillers and stomach medicine and generally takes six days, said Dr. Darin Meulebroeck, chief medical officer for Avianax. The trials have shown the new drug can work quickly as two days, he said.

“We’ve lost a couple that have been so severe . . . there’s no drug that is going to treat 100 percent of everything,” Meulebroeck said.

The tests run through November.

Glynn said Avianax has “stuck in there” with the help of key researchers and believes it is on the verge of saving human lives with a similar antibody – although it could take more than five years to reach the market. The U.S. Army is interested in using the technology for Andres virus, which has been found to lead to a fatal respiratory disease. Safety trials are scheduled in the next two years.

“We went from being goose herders from South Dakota to an antibody company,” Glynn said. “And we’re not done yet.”

The Associated Press

The Associated Press

LEAVE A COMMENT

Discussion | No comments

The Daily Republic does not necessarily condone the comments here, nor does it review every post. Read our full policy

.

Solano News

 
Health officials report 1st Solano flu death

By Kevin W. Green | From Page: A1 | Gallery

 
Fairfield man who says he accidentally kicked woman, faces charges

By Ryan McCarthy | From Page: A5 | Gallery

 
 
American Legion Post schedules head-shaving fundraiser

By Kevin W. Green | From Page: A6

Rush Ranch seeks docents

By Kevin W. Green | From Page: A2

 
Dramas, thrillers lead week’s box office openings

By Amy Maginnis-Honey | From Page: B6

Vacaville Toastmasters welcome guests

By Amy Maginnis-Honey | From Page: A6

 
Kroc Health Fair offers free screenings

By Amy Maginnis-Honey | From Page: A1

 
Chipotle fundraiser to benefit Armijo newspaper

By Amy Maginnis-Honey | From Page: A6

Vacaville council eyes earlier start time

By Ryan McCarthy | From Page:

 
.

US / World

Facebook suffers outage affecting users worldwide

By The Associated Press | From Page:

 
Private wells in California farm area show high uranium

By The Associated Press | From Page: B2

Budget for Koch-backed network: almost $1 billion for 2016

By The Associated Press | From Page: B2

 
Ex-Army prosecutor found guilty of rape at court-martial

By The Associated Press | From Page: B2

California may dam 3 Delta channels, if drought persists

By The Associated Press | From Page: B2

 
Law enforcement wants popular police-tracking app disabled

By The Associated Press | From Page: B2

Gov’t to overhaul Medicare payments to doctors, hospitals

By The Associated Press | From Page: B2

 
Cuban youth build secret computer network despite Wi-Fi ban

By The Associated Press | From Page: B2 | Gallery

Seekers of the Hollywood Sign disrupt nearby neighborhood

By The Associated Press | From Page: A2 | Gallery

 
2 small planes crash-land off Hawaii; all aboard survive

By The Associated Press | From Page: B2

Report: State worker sent alarming notes before gun arrest

By The Associated Press | From Page: B2 | Gallery

 
Panic attack, bad back: Theater shooting brings jury excuses

By The Associated Press | From Page: B2

Lawyer: Boy Scout files depict ‘sordid’ history of abuse

By The Associated Press | From Page: B2

 
Dwindling group of survivors to mark Auschwitz 70 years on

By The Associated Press | From Page: B2 | Gallery

New Jersey’s Christie launches political action committee

By The Associated Press | From Page: B2

 
US drone strikes resume in Yemen despite turmoil

By The Associated Press | From Page: B2

Monster snowstorm swirls into densely populated Northeast US

By The Associated Press | From Page: B2 | Gallery

 
Kurds celebrate ousting Islamic State fighters from Kobani

By The Associated Press | From Page: B2

Man takes responsibility for drone over White House

By The Associated Press | From Page: B2 | Gallery

 
.

Opinion

2 sides to state highways rehab backlog

By Dan Walters | From Page: A11

 
.

Living

Community Calendar: Jan. 27, 2015

By Susan Hiland | From Page: A2

 
.

Entertainment

Petty earns writing credit for Sam Smith’s ‘Stay With Me’

By The Associated Press | From Page: B3

 
National Cowboy Poetry Gathering begins in northeast Nevada

By The Associated Press | From Page: B3

Trainor and Styles write a duet about heartbreak

By The Associated Press | From Page: B3

 
Emma Watson to star in live-action ‘Beauty and the Beast’

By The Associated Press | From Page: B3

 
SAG Awards win sends ‘Birdman’ Oscar hopes soaring

By The Associated Press | From Page: B3

Cumberbatch says sorry for calling black actors ‘colored’

By The Associated Press | From Page: B3

 
A murder at the edge of the world takes ‘Fortitude’ to crack

By The Associated Press | From Page: B3 | Gallery

Lawyers: Melissa Rivers files lawsuit in mother Joan’s death

By The Associated Press | From Page: B3 | Gallery

 
Sundance Watch: ‘Cobain’ premieres, women talk Hollywood

By The Associated Press | From Page: B3

TVGrid Jan 27

By Daily Republic Syndicated Content | From Page: B7

 
.

Sports

Manfred knows he’ll get hit as commish _ his name is on ball

By The Associated Press | From Page: B1 | Gallery

 
NASCAR to leave championship format unchanged in 2015

By The Associated Press | From Page: B1

 
Kobe Bryant to have shoulder surgery, likely out for season

By The Associated Press | From Page: B1 | Gallery

Tim Brown hopes 6th time is charm in Hall of Fame vote

By The Associated Press | From Page: B1

 
Raiders sign Charles Woodson for 2015 season

By The Associated Press | From Page: B1

Rams notify St. Louis they’ll go year-to-year on dome lease

By The Associated Press | From Page: B1

 
Gamecocks still No. 1; Chattanooga joins women’s hoops poll

By The Associated Press | From Page: B1

Scott Dixon shines in masterful final drive in Rolex win

By The Associated Press | From Page: B1 | Gallery

 
LeBron, Cavs climb in standings, back in title conversation

By The Associated Press | From Page: B1

Capitals among East contenders; West race too tight to call

By The Associated Press | From Page: B1

 
Playoff not interested in moving semis of New Year’s Eve

By The Associated Press | From Page: B1

Fireworks help celebrate Venus Williams’ Australian Open run

By The Associated Press | From Page: B1

 
US women to host New Zealand, Ireland, Mexico, South Korea

By The Associated Press | From Page: B1

NBA D-League All-Star events set for Feb. 15 in Brooklyn

By The Associated Press | From Page: B1

 
AP Source: Los Angeles Kings release Mike Richards

By The Associated Press | From Page: B1

Hope Solo could be left off US World Cup roster

By The Associated Press | From Page: B1 | Gallery

 
.

Business

Employers: Agreement made on key issue in port labor dispute

By The Associated Press | From Page: B4

 
Lyft cars doing away with pink furry mustache

By The Associated Press | From Page: B4

California draws $3.2 billion in federal health subsidies

By The Associated Press | From Page: B4

 
Hard Rock (again) dips toe into Atlantic City casino market

By The Associated Press | From Page: B1

US stock market finishes with small gains

By The Associated Press | From Page: B4

 
IBM disputes report that big layoffs coming

By The Associated Press | From Page: B4

Union says California Kaiser nurses reach contract agreement

By The Associated Press | From Page: B4

 
Boeing, SpaceX will beat Russia on price for astronaut rides

By The Associated Press | From Page: B4 | Gallery

CBO: Deficit to shrink to lowest level of Obama presidency

By The Associated Press | From Page: B4

 
Eurozone looks for dialogue after stunning Greece elections

By The Associated Press | From Page: B4

S&P downgrades Russia credit rating to junk

By The Associated Press | From Page: B4

 
.

Obituaries

Donald Wesley Johnson

By Susan Hiland | From Page: A4

 
.

Comics

Rose is Rose Jan 27

By Daily Republic Syndicated Content | From Page: B4

 
Get Fuzzy Jan 27

By Daily Republic Syndicated Content | From Page: B4

Beetle Bailey Jan 27

By Daily Republic Syndicated Content | From Page: B4

 
B.C. Jan 27

By Daily Republic Syndicated Content | From Page: B4

Cryptoquote Jan 27

By Daily Republic Syndicated Content | From Page: B5

 
For Better or Worse Jan 27

By Daily Republic Syndicated Content | From Page: B4

Dilbert Jan 27

By Daily Republic Syndicated Content | From Page: B4

 
Bridge Jan 27

By Daily Republic Syndicated Content | From Page: B5

Garfield Jan 27

By Daily Republic Syndicated Content | From Page: B4

 
Crossword Jan 27

By Daily Republic Syndicated Content | From Page: B5

Baby Blues Jan 27

By Daily Republic Syndicated Content | From Page: B4

 
Pickles Jan 27

By Daily Republic Syndicated Content | From Page: B4

Sally Forth Jan 27

By Daily Republic Syndicated Content | From Page: B4

 
Baldo Jan 27

By Daily Republic Syndicated Content | From Page: B4

Wizard of Id Jan 27

By Daily Republic Syndicated Content | From Page: B4

 
Word Sleuth Jan 27

By Daily Republic Syndicated Content | From Page: B5

Frank and Ernest Jan 27

By Daily Republic Syndicated Content | From Page: B4

 
Sudoku Jan 27

By Daily Republic Syndicated Content | From Page: B5

Blondie Jan 27

By Daily Republic Syndicated Content | From Page: B4

 
Zits Jan 27

By Daily Republic Syndicated Content | From Page: B4

Peanuts Jan 27

By Daily Republic Syndicated Content | From Page: B4