Thursday, April 24, 2014
FAIRFIELD-SUISUN, CALIFORNIA
99 CENTS

New drug, study method show breast cancer promise

SAN ANTONIO — A novel way to speed the testing of cancer drugs and quickly separate winners from duds has yielded its first big result: an experimental medicine that shows promise against a hard-to-treat form of breast cancer.

The method involves studying drugs in small groups of people and using advanced statistical techniques to analyze the results as they come in, instead of waiting for all the data to arrive.

Whether the drug, veliparib, ever makes it to market remains to be seen, but it has shown enough potential to advance to final-phase testing aimed at Food and Drug Administration approval.

Bringing a new cancer drug to market usually takes more than a decade and tests in thousands of patients, and costs more than $1 billion. Companies can’t afford many studies like that, and patients can’t wait years for potentially life-saving new medicines, said Don Berry, a biostatistician at the University of Texas MD Anderson Cancer Center.

He helped design the novel analytical method discussed Friday at the San Antonio Breast Cancer Symposium, an international conference.

Researchers testing a drug usually don’t see results until they’re all in, to prevent biasing the study. But several years ago, an unusual partnership decided to try a new way. It involves the National Cancer Institute, the FDA, drug companies, dozens of cancer research centers and charitable foundations.

The study, called I-SPY 2, puts small groups of women on experimental drugs or combinations, then gives them surgery to see what effect the medicines had. The best result is a complete response, where no signs of cancer remain.

Each patient’s results are analyzed as they come in, and advanced statistical methods are used to calculate probabilities that the drug would help in various situations, depending on which women had a complete response.

“This allows us to learn and adapt from each patient as the study goes on,” and results on early participants guide treatment that later ones get, said Dr. Hope Rugo of the University of California, San Francisco. When enough evidence indicates a high probability of success, the drug “graduates” to final-phase testing.

On Friday, Rugo gave results on veliparib, the first of seven drugs being tested. It is made by AbbVie Inc., a North Chicago, Ill., company recently spun off from Abbott Laboratories. It is in a new class of experimental medicines called PARP inhibitors, which target an enzyme cancer relies on to grow.

The I-SPY 2 testing suggests that adding the chemotherapy drug carboplatin and veliparib to usual chemo before surgery improved outcomes for women with “triple negative” breast cancer – tumors that are not fueled by estrogen, progesterone or the gene that the medicine Herceptin targets.

Up to 20 percent of breast cancers are this type, and they are more common in young women, blacks and Hispanics, and women with certain breast cancer gene mutations.

Researchers were able to determine the drug’s potential after tests in only 71 women and just six months of treatment. They calculated that tests of only 300 women with triple negative tumors are needed to give a definitive answer, and that the drug has at least a 90 percent probability of success in such patients. If more types of cancer are included, the probability of success drops to 55 percent.

The results show that “we can get early reads on something that is worth pursuing” and bail quickly on treatments that don’t help, said Dr. Carlos Arteaga of the Vanderbilt-Ingram Comprehensive Cancer Center.

Veliparib has now graduated and is eligible for testing in a definitive study. It’s not known how long that would take, but it surely would be shorter than the several years that traditional testing requires.

FDA officials have said that in certain cases, complete responses can be considered a basis for conditional approval of a drug, as long as follow-up tests are done after the product is on the market to prove that it indeed is improving survival.

Last week, another company participating in the I-SPY 2 study, Puma Biotechnology Inc., said its experimental drug neratinib had also graduated and would enter a definitive study. Results of the early testing will be presented at a cancer conference next year.

The San Antonio meeting is sponsored by the American Association for Cancer Research, Baylor College of Medicine and the UT Health Science Center.

___

Online:

I-SPY2 trial: http://www.ispy2.org

Cancer meeting: http://www.sabcs.org

The Associated Press

The Associated Press

LEAVE A COMMENT

Discussion | No comments

The Daily Republic does not necessarily condone the comments here, nor does it review every post. Read our full policy

.

Solano News

 
Congressman talks Travis, water

By Barry Eberling | From Page: A1, 4 Comments | Gallery

Travis lines up 2 days of aviation excellence

By Ian Thompson | From Page: A1, 1 Comment | Gallery

 
Appreciate how good we have it now

By Angela Borchert | From Page: A2

 
 
Dixon May Fair has deals on advance tickets

By Amy Maginnis-Honey | From Page: A3

 
Garamendi talks love, pro football and Peace Corps

By Ryan McCarthy | From Page: A3, 4 Comments | Gallery

 
Author to sign books at Vacaville Museum

By Amy Maginnis-Honey | From Page: A3

Kroc Center women schedule inaugural Taster Tea

By Amy Maginnis-Honey | From Page: A3

 
Docents to lead paddling tour in marsh

By Adrienne Harris | From Page: A4

Juneteenth committee extends vendors, exhibitors deadline

By Amy Maginnis-Honey | From Page: A4

 
Congressional Art Competition is back

By Susan Hiland | From Page: A4

 
Spilled tomato juice case set for trial

By Ryan McCarthy | From Page: A4, 5 Comments

Theme park welcomes seal pup

By Adrienne Harris | From Page: A4

 
 
Suisun City police log: April 22, 2014

By Susan Hiland | From Page: A12

 
Suisun City police log: April 21, 2014

By Susan Hiland | From Page: A12

Fairfield police log: April 21, 2014

By Susan Hiland | From Page: A12

 
Weather for Thursday, April 24, 2014

By Daily Republic staff | From Page: B12

Fairfield police log: April 22, 2014

By Susan Hiland | From Page: A12

 
.

US / World

Syrian activists accuse Assad of new gas attacks

By The Associated Press | From Page: A1

 
Murder charge for Vallejo man in head-on crash

By The Associated Press | From Page: A5, 1 Comment

California bill reignites affirmative action fight

By The Associated Press | From Page: A5, 3 Comments

 
Andy Lopez protest leads to school campus lockdown

By The Associated Press | From Page: A5, 3 Comments

Navy Cross bestowed on heroic Marine

By The Associated Press | From Page: A5, 1 Comment

 
Airport official: Teen had no clue he was in Maui

By The Associated Press | From Page: A5

US weighs clemency for inmates jailed for 10 years

By The Associated Press | From Page: A6, 1 Comment

 
Gun carry rights expanded in Ga. under new law

By The Associated Press | From Page: A6, 4 Comments

First lady announces one-stop job site for vets

By The Associated Press | From Page: A6, 2 Comments

 
Rail safety effort marred by squabbling

By The Associated Press | From Page: A6, 1 Comment

Small Wyoming town evacuated after gas explosion

By The Associated Press | From Page: A6

 
Bashtag: NYPD Twitter campaign backfires

By The Associated Press | From Page: A6, 1 Comment

Soldier convicted in WikiLeaks case gets new name

By The Associated Press | From Page: A6

 
Lawyer: US man held in Cuba seeks to go home soon

By The Associated Press | From Page: A10, 1 Comment

Captain who left doomed ferry had 40 years at sea

By The Associated Press | From Page: A10

 
Russian social media CEO quits, flees country

By The Associated Press | From Page: A10

Amid Russia warning, Ukraine is in a security bind

By The Associated Press | From Page: A10, 1 Comment

 
Palestinian rivals to try again for unity deal

By The Associated Press | From Page: A10

Camilla’s brother dies in US after head injury

By The Associated Press | From Page: A10

 
State senators get ethics training after scandals

By The Associated Press | From Page: A12, 7 Comments

.

Opinion

Question of the week: Will Flight 370 be found?

By Daily Republic | From Page: A11

 
Be the first and give specifics

By Letter to the Editor | From Page: A11, 2 Comments

What we can do about crime

By Kelvin Wade | From Page: A11, 14 Comments

 
Castro at odds with mentor on deportations

By Ruben Navarrette | From Page: A11

Some Earth Day boos and cheers

By Jay Ambrose | From Page: A11

 
.

Living

Today in History for April 24, 2014

By The Associated Press | From Page: A2

 
Community Calendar: April 24, 2014

By Susan Hiland | From Page: A2

When Joe’s mad at me, he also ignores my 7-year-old son

By Kathy Mitchell and Marcy Sugar | From Page: A9

 
Horoscopes for April 24, 2014

By Holiday Mathis | From Page: A9

.

Entertainment

TVGrid

By Daily Republic Syndicated Content | From Page: B5

 
Jodie Foster weds artist Alexandra Hedison

By The Associated Press | From Page: A7

Singer Chris Brown’s DC trial delayed for months

By The Associated Press | From Page: A7

 
Performing dogs go big after $1 million TV prize

By The Associated Press | From Page: A7

Amazon snares classic shows in deal with HBO

By The Associated Press | From Page: A7

 
.

Sports

Mustangs swim to sweep of Indians

By Marcus Lomtong | From Page: B1 | Gallery

 
Warriors, Clippers to meet in Oakland for Game 3

By The Associated Press | From Page: B1

Sharks confident with chance to sweep LA Kings

By The Associated Press | From Page: B1

 
Girls soccer update: Armijo, Vanden on way to playoffs

By Paul Farmer | From Page: B1 | Gallery

A’s reject 10-year Coliseum lease offer

By The Associated Press | From Page: B2

 
Prep softball: Vanden rolls to 14-0 win over Fairfield

By Daily Republic staff | From Page: B2

 
Prep badminton: Unbeaten Mustangs cruise past Crushers

By Daily Republic staff | From Page: B2

Prep boys golf: Vikings suffer SCAC loss to Panthers

By Daily Republic staff | From Page: B2

 
Sanchez’s slam in 11th helps Giants beat Rox 12-10

By The Associated Press | From Page: B2 | Gallery

Prep track: Armijo girls get win in MEL 4-way meet

By Daily Republic staff | From Page: B2

 
Perez helps Rangers sweep A’s with 3-0 win

By The Associated Press | From Page: B2 | Gallery

Party a century in the making for Wrigley Field

By The Associated Press | From Page: B2

 
Emmert supports more efficient, effective NCAA

By The Associated Press | From Page: B3

Phelps having fun in his return to swimming

By The Associated Press | From Page: B3 | Gallery

 
Suns’ Dragic honored as NBA’s Most Improved Player

By The Associated Press | From Page: B3

Seahawks to open NFL season vs. Packers

By The Associated Press | From Page: B3

 
Oldest living ex-MLB player dies in Cuba at 102

By The Associated Press | From Page: B12

 
.

Business

Wellness programs grow more popular with employers

By The Associated Press | From Page: B5

 
Sales of new US homes plunge 14.5 percent in March

By The Associated Press | From Page: B6

Buffett disapproves of Coca-Cola’s pay plan

By The Associated Press | From Page: B6

 
Amazon snares classic shows in deal with HBO

By The Associated Press | From Page: B6

US stocks edge lower after a six-day rise

By The Associated Press | From Page: B6

 
Facebook 1Q results soar; CFO to step down

By The Associated Press | From Page: B6

Apple increases stock buyback, will split stock

By The Associated Press | From Page: B6, 1 Comment

 
.

Obituaries

Phyllis J. Miller

By Nancy Green | From Page: A4

 
Dondi Martin

By Nancy Green | From Page: A4

.

Comics

Rose is Rose

By Daily Republic Syndicated Content | From Page: A8

 
Garfield

By Daily Republic Syndicated Content | From Page: A8

Pickles

By Daily Republic Syndicated Content | From Page: A8

 
For Better or Worse

By Daily Republic Syndicated Content | From Page: A8

Peanuts

By Daily Republic Syndicated Content | From Page: A8

 
Wizard Of Id

By Daily Republic Syndicated Content | From Page: A8

Dilbert

By Daily Republic Syndicated Content | From Page: A8

 
Baldo

By Daily Republic Syndicated Content | From Page: A8

Blondie

By Daily Republic Syndicated Content | From Page: A8

 
Baby Blues

By Daily Republic Syndicated Content | From Page: A8

Beetle Bailey

By Daily Republic Syndicated Content | From Page: A8

 
Sally Forth

By Daily Republic Syndicated Content | From Page: A8

B.C.

By Daily Republic Syndicated Content | From Page: A8

 
Frank and Ernest

By Daily Republic Syndicated Content | From Page: A8

Get Fuzzy

By Daily Republic Syndicated Content | From Page: A8

 
Zits

By Daily Republic Syndicated Content | From Page: A8

Cryptoquote

By Daily Republic Syndicated Content | From Page: A9

 
Crossword

By Daily Republic Syndicated Content | From Page: A9

Word Sleuth

By Daily Republic Syndicated Content | From Page: A9

 
Bridge

By Daily Republic Syndicated Content | From Page: A9

Sudoku

By Daily Republic Syndicated Content | From Page: A9