Monday, December 22, 2014
FAIRFIELD-SUISUN, CALIFORNIA
99 CENTS

Doctors use immune therapy against cervical cancer

By
June 04, 2014 |

CHICAGO — Two years ago, Arrica Wallace was riddled with tumors from widely spread cervical cancer that the strongest chemotherapy and radiation could not beat back. Today, the Kansas mother shows no signs of the disease, and it was her own immune system that made it go away.

The experimental approach that helped her is one of the newest frontiers in the rapidly advancing field of cancer immunotherapy, which boosts the body’s natural ways of attacking tumors.

At a conference in Chicago on Monday, doctors also reported extending gains recently made with immune therapies against leukemia and the skin cancer melanoma to bladder, lung and other tumor types.

The cervical cancer experiment was the first time an immune therapy has worked so dramatically against a cancer caused by a virus – HPV. In a pilot study by the National Cancer Institute, the tumors of two out of nine women completely disappeared and those women remain cancer-free more than a year later. That’s far better than any other treatment has achieved in such cases.

Doctors are trying it now against throat, anal and other cancers caused by HPV, the human papillomavirus, and think it holds promise for cancers caused by other viruses, too.

This is “very, very exciting,” said Dr. Don Dizon of Massachusetts General Hospital, a women’s cancer specialist with no role in the study.

Wallace lives in Manhattan, Kansas, west of Topeka, and was 35 when her cervical cancer was discovered. It spread widely, and one tumor was so large it blocked half of her windpipe. Doctors said she had less than a year to live, but with sons aged 8 and 12, “I couldn’t give up,” she said.

She enrolled in the study, and researchers removed one of her tumors, isolated special immune system cells that were attacking it, multiplied them in the lab and gave billions of them back to her in a one-time infusion. They also gave her drugs to boost her immune response – “like Gatorade for the cells,” she said.

“It’s been 22 months since treatment and 17 months of completely clean scans” showing no sign of cancer, Wallace said.

The second woman to have a complete response has been cancer-free for 15 months so far, said one study leader, Dr. Christian Hinrichs of the Bethesda, Maryland-based cancer institute.

“There’s no way to know” if the results will be permanent, he said.

A third woman had tumor shrinkage that lasted three months. The other six women did not respond to treatment and researchers are attempting to determine why.

Doctors are trying the treatment on several dozen more women with advanced cervical cancer and it could someday be offered at many cancer centers the way bone marrow and stem cell transplants are now.

Many private companies are pursuing other treatments that are given like drugs aimed at the immune system. Also discussed at the American Society of Clinical Oncology conference:

  • Bristol-Myers Squibb Co.’s Yervoy, the first immune therapy to improve survival of advanced, inoperable melanoma, also helped prevent recurrence when given to people with earlier stage disease at regular intervals after surgery, a study of nearly 1,000 patients found. But severe side effects caused half to quit treatment, and five people died from it. Doctors think a lower dose might minimize these problems. The drug also costs more than $100,000 for initial treatment, so long-term cost is a concern.
  • Nivolumab, an experimental therapy from Bristol-Myers, extended survival by 3 1/2 years on average when given with Yervoy to people with very advanced melanoma, far better than any previous treatments. Nine of 53 patients treated had complete remissions.
  • Merck & Co.’s experimental therapy pembrolizumab gave one-year survival rates of about 69 percent in a study of 411 patients with very advanced melanoma, including many previously treated with Yervoy.
  • Genentech’s experimental immune therapy for bladder cancer shrank tumors in 13 of 30 patients with advanced bladder cancer for which there are hardly any treatment options now. All signs of cancer disappeared in two patients.

Immune therapy struggled for years with just occasional small gains, but “now we have cruise missiles” giving better kill rates against many tumor types, said Dr. Steven O’Day of the University of Southern California.

Others tempered their enthusiasm, noting that some promising approaches produced more limited gains once they were more fully researched.

“Let’s not forget the history” of what seems like progress with a new approach, said Dr. Len Lichtenfeld, deputy chief medical officer of the American Cancer Society. “It doesn’t always work out the way it appears to be heading.”

The Associated Press

The Associated Press

LEAVE A COMMENT

Discussion | No comments

The Daily Republic does not necessarily condone the comments here, nor does it review every post. Read our full policy

.

Solano News

Christmas comes early to San Marco Street park

By Ryan McCarthy | From Page: A1 | Gallery

 
Travis squadron delivers Christmas gifts to East Tabor

By Ryan McCarthy | From Page: A1 | Gallery

How this chunky Wade met Chunky Wade

By Tony Wade | From Page: A2

 
Multiple car accident blocks I-80 in Vacaville

By Glen Faison | From Page: A3, 1 Comment | Gallery

 
Solano Kwanzaa celebration set for Vallejo return

By Susan Hiland | From Page: A3

 
Lawyers off free legal advice in Fairfield

By Susan Hiland | From Page: A3

 
 
Kitchen fire dislocates family for Christmas

By Susan Hiland | From Page: A4 | Gallery

Famous Creations’ toy drive and cupcake sale

By Daily Republic staff | From Page: A4 | Gallery

 
Last-minute shopping at Vacaville Premium Outlets

By Daily Republic staff | From Page: A4 | Gallery

Fairfield police log: Dec. 20, 2014

By Susan Hiland | From Page: A9

 
Suisun City police log: Dec. 20, 2014

By Susan Hiland | From Page: A9

Weather for Dec. 22, 2014

By Daily Republic | From Page: B10

 
.

US / World

Killer of 2 NYC officers had long criminal history

By The Associated Press | From Page: A1

 
Killings of 2 New York officers trigger backlash

By The Associated Press | From Page: A1

California puzzles over safety of driverless cars

By The Associated Press | From Page: A1

 
Timeline of events before and after NY cop deaths

By The Associated Press | From Page: A1

A look at the 2 NYC officers killed in ambush

By The Associated Press | From Page: A1

 
What’s being said about killings of 2 NYC officers

By The Associated Press | From Page: A1

Pakistan makes arrests in Taliban school carnage

By The Associated Press | From Page: A5

 
Florida authorities say 1 police officer shot and killed

By The Associated Press | From Page: A5

Tent city sprouts in shadow of downtown Detroit

By The Associated Press | From Page: A5

 
US mulls putting NKorea on terrorism sponsor list

By The Associated Press | From Page: A5

Satanic Temple puts up display at Michigan Capitol

By The Associated Press | From Page: A5

 
Australian woman charged with murder of 8 children

By The Associated Press | From Page: A5

Exit poll: Ex-regime official is Tunisia’s new president

By The Associated Press | From Page: A5

 
.

Opinion

Faust and the 2015 federal budget

By Mike Kirchubel | From Page: A8

 
Obama, surgeon general still losing to NRA

By Francis Wilkinson | From Page: A8

Let the music begin

By Colleen Britton | From Page: A8

 
Editorial Cartoon: Dec. 22, 2014

By Daily Republic Syndicated Content | From Page: A8

 
.

Living

Community Calendar: Dec. 22, 2014

By Susan Hiland | From Page: A2

 
Today in History: Dec. 22, 2014

By The Associated Press | From Page: A2

Horoscopes: Dec. 23, 2014

By Holiday Mathis | From Page: B5

 
 
Horoscopes: Dec. 22, 2014

By Holiday Mathis | From Page: A7

.

Entertainment

TVGrid Dec 22

By Daily Republic Syndicated Content | From Page: B6

 
‘Hobbit’ goes out on top with $90.6 million 5-day debut

By The Associated Press | From Page: B7

Good news from Tom Brokaw: His cancer is in remission

By The Associated Press | From Page: B7

 
Review: ‘The Interview’ deserves to be seen

By Jake Coyle | From Page: B7

Happy day: Elton John, David Furnish marry in England

By The Associated Press | From Page: B7

 
TVGrid Dec 23

By Daily Republic Syndicated Content | From Page: B7

.

Sports

Kings snap 5-game losing skid, beat Lakers 108-101

By The Associated Press | From Page: B1 | Gallery

 
Burns gives Sharks late-night win over Blues in OT

By The Associated Press | From Page: B1

The Week Ahead: Not much of a break for Christmas

By Paul Farmer | From Page: B1

 
Steelers, Packers win, move into playoffs

By The Associated Press | From Page: B1 | Gallery

Raiders knock Bills out of playoffs with 26-24 win

By The Associated Press | From Page: B1 | Gallery

 
Super-G crash makes Vonn wait in bid for record

By The Associated Press | From Page: B2

NFL Roundup: Cowboys end 4-year drought, make playoffs

By The Associated Press | From Page: B2 | Gallery

 
7 hurt when lightning strikes near Tampa Bay game

By The Associated Press | From Page: B2

India’s Arjun Atwal wins Dubai Open

By The Associated Press | From Page: B2

 
Documents: FSU QB Winston cleared in conduct hearing

By The Associated Press | From Page: B2

.

Business

US companies eager to embrace Cuba face hurdles

By The Associated Press | From Page: B6

 
Survey: US gas prices fall 25 cents per gallon

By The Associated Press | From Page: B6

.

Obituaries

Marian Kay Zutz

By Nancy Green | From Page: A4

 
Bart Ferro

By Nancy Green | From Page: A4

.

Comics

Wizard of Id Dec 23

By Daily Republic Syndicated Content | From Page: B4

 
Baby Blues Dec 23

By Daily Republic Syndicated Content | From Page: B4

Zits Dec 23

By Daily Republic Syndicated Content | From Page: B4

 
Get Fuzzy Dec 23

By Daily Republic Syndicated Content | From Page: B4

Pickles Dec 23

By Daily Republic Syndicated Content | From Page: B4

 
Rose is Rose Dec 23

By Daily Republic Syndicated Content | From Page: B4

Beetle Bailey Dec 23

By Daily Republic Syndicated Content | From Page: B4

 
Peanuts Dec 23

By Daily Republic Syndicated Content | From Page: B4

Garfield Dec 23

By Daily Republic Syndicated Content | From Page: B4

 
For Better or Worse Dec 23

By Daily Republic Syndicated Content | From Page: B4

Baldo Dec 23

By Daily Republic Syndicated Content | From Page: B4

 
Blondie Dec 23

By Daily Republic Syndicated Content | From Page: B4

Dilbert Dec 23

By Daily Republic Syndicated Content | From Page: B4

 
Frank and Ernest Dec 23

By Daily Republic Syndicated Content | From Page: B4

Sally Forth Dec 23

By Daily Republic Syndicated Content | From Page: B4

 
B.C. Dec 23

By Daily Republic Syndicated Content | From Page: B4

Crossword Dec 23

By Daily Republic Syndicated Content | From Page: B5

 
Cryptoquote Dec 23

By Daily Republic Syndicated Content | From Page: B5

Sudoku Dec 23

By Daily Republic Syndicated Content | From Page: B5

 
Bridge Dec 23

By Daily Republic Syndicated Content | From Page: B5

Word Sleuth Dec 23

By Daily Republic Syndicated Content | From Page: B5

 
Blondie Dec 22

By Daily Republic Syndicated Content | From Page: A6

Beetle Bailey Dec 22

By Daily Republic Syndicated Content | From Page: A6

 
Garfield Dec 22

By Daily Republic Syndicated Content | From Page: A6

B.C. Dec 22

By Daily Republic Syndicated Content | From Page: A6

 
Wizard of Id Dec 22

By Daily Republic Syndicated Content | From Page: A6

For Better or Worse Dec 22

By Daily Republic Syndicated Content | From Page: A6

 
Get Fuzzy Dec 22

By Daily Republic Syndicated Content | From Page: A6

Baby Blues Dec 22

By Daily Republic Syndicated Content | From Page: A6

 
Baldo Dec 22

By Daily Republic Syndicated Content | From Page: A6

Zits Dec 22

By Daily Republic Syndicated Content | From Page: A6

 
Peanuts Dec 22

By Daily Republic Syndicated Content | From Page: A6

Dilbert Dec 22

By Daily Republic Syndicated Content | From Page: A6

 
Sally Forth Dec 22

By Daily Republic Syndicated Content | From Page: A6

Pickles Dec 22

By Daily Republic Syndicated Content | From Page: A6

 
Rose is Rose Dec 22

By Daily Republic Syndicated Content | From Page: A6

Frank and Ernest Dec 22

By Daily Republic Syndicated Content | From Page: A6

 
Word Sleuth Dec 22

By Daily Republic Syndicated Content | From Page: A7

Crossword Dec 22

By Daily Republic Syndicated Content | From Page: A7

 
Sudoku Dec 22

By Daily Republic Syndicated Content | From Page: A7

Cryptoquote Dec 22

By Daily Republic Syndicated Content | From Page: A7

 
Bridge Dec 22

By Daily Republic Syndicated Content | From Page: A7