Drew Brees and the New Orleans Saints wound up with egg on their faces.

After racing to a 17-0 lead, the Falcons turned to their defense to make it stand up, picking off five of Brees’ passes and ending his NFL-record touchdown streak in a 23-13 victory over the Saints on Thursday night.

The Falcons (11-1) will clinch the NFC South with a month to go if Tampa Bay loses at Denver on Sunday. They also dealt a big blow to the Saints (5-7) and their fading playoff hopes.

William Moore had two of the five interceptions, which were the most of Brees’ career and came four days after he had two passes picked off and returned for touchdowns in a loss to San Francisco.

Brees had thrown a touchdown pass in 54 consecutive games, breaking Johnny Unitas’ long-standing record earlier this season. He had an apparent scoring pass to Darren Sproles late in the first half, but it was nullified by a penalty.

“I didn’t realize that until we walked off the field,” Falcons coach Mike Smith said. “That’s an unbelievable streak. Drew Brees is an outstanding quarterback. The way the defense played tonight speaks volumes. The guys had gone out there and thrown touchdown after touchdown game after game after game.”

When the Saints arrived in Atlanta, their bus was pelted by eggs at the airport, a sign of the long rivalry between the teams. New Orleans had dominated in recent years, winning four in a row and 11 of 13.

This time, Michael Turner scored on Atlanta’s opening possession, Tony Gonzalez hauled in a touchdown pass from Matt Ryan, and Matt Bryant booted three field goals, including a 55-yarder.

The defense did the rest. Thomas DeCoud, Sean Weatherspoon and Jonathan Babineaux also had interceptions for Atlanta, and another pick by Corey Peters was wiped out by a penalty.

Brees had a couple of games with four picks, but nothing like this. He finished 28 of 50 for 341 yards.

The defending NFC South champion Saints lost their second in a row and will likely have to win out to have even a faint hope of making the postseason during a tumultuous year that was marred by a bounty scandal and a season-long suspension for coach Sean Payton.

After winning so many close games, the Falcons started this one as if they were intent on a rout.

Ryan completed a pass on the first play from scrimmage, then turned it over to a running game that has struggled most of the season. Turner burst around right end for a 35-yard gain. Jacquizz Rodgers broke off two straight 14-yard gains. Finally, it was Turner going in standing from 3 yards out, giving Atlanta a quick 7-0 lead.

That was Turner’s 58th touchdown in five seasons with the Falcons, breaking the team record he had shared with Terance Mathis.

Atlanta struck again in the opening minute of the second period. Julio Jones hauled in an 18-yard throw from Ryan, setting up a 17-yard touchdown pass to Gonzalez in the back of the end zone. He beat former teammate Curtis Lofton, then just flipped the ball over the goalposts instead of his customary basketball dunk.

Brees’ second interception, this one a sloppy pass behind running Chris Ivory that deflected into the arms of Sean Weatherspoon, set up Bryant’s 45-yard field goal for a 17-0 lead.

Then, suddenly, the game completely changed.

For the rest of the second quarter and most of the third, the Saints totally dominated. Mark Ingram scored on a 1-yard run, capping an 11-play, 80-yard drive, and New Orleans should have tacked on more points at the end of the half. But Brees made a rookie-like mistake with 12 seconds remaining, dumping a pass over the middle to Sproles with no timeouts. He was wrapped up at the Atlanta 3 and the clock ran out before the Saints could spike the ball.

But New Orleans got the ball to start the second half, and Brees went back to work. This time, he made a couple of nifty moves to avoid sacks, completing six passes on an 83-yard drive consuming 15 plays and more than 6 1/2 minutes. But the Falcons held again, forcing Garrett Hartley to boot a 21-yard field goal that cut it to 17-10.

Hartley connected again from much farther out on the Saints’ next possession, a 52-yarder that brought New Orleans even closer.

The Falcons, meanwhile, couldn’t do anything offensively. They failed to pick up a first down on five straight possessions, a stretch in which the Saints had a 289-30 lead in total yards and a staggering 18 first downs.

Finally, it was the Atlanta defense that turned things around late in the third.

Brees rolled to his right and threw over the middle, but Moore picked off the pass and returned it to the New Orleans 16. Ryan connected on first-down throws to Gonzalez and Roddy White to set up Bryant’s field goal.